Treatment of high-risk gestational trophoblastic neoplasia and chemoresistance/relapsed disease
نویسندگان
چکیده
منابع مشابه
Efficacy of combination therapy of Methotrexate and Vitamin A in low risk gestational trophoblastic neoplasia treatment
Introduction: Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the e...
متن کاملEfficacy of combination therapy of Methotrexate and Vitamin A in low risk gestational trophoblastic neoplasia treatment
Introduction: Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the e...
متن کاملTreatment of metastatic gestational trophoblastic neoplasia.
Treatment of persistent gestational trophoblastic neoplasia (GTN) has been one of the success stories of modern day chemotherapy; however, occasional patients with metastatic disease still die. A potential difficulty in assessing published studies is that patient groups can be selected for treatment differently according to how risk categories are defined. The involvement of a specialist team f...
متن کاملGestational trophoblastic neoplasia.
Trophoblastic neoplasms are a truly fascinating set of diseases that arise from a failed gestation. A molar pregnancy is an allograft of fetal tissue typically containing only paternal chromosomes that may invade the maternal decidua following a failed gestation that may have arisen up to decades earlier. Choriocarcinoma (CCA), the most common malignant form of trophoblastic disease, represente...
متن کاملTreatment of extremely high risk and resistant gestational trophoblastic neoplasia patients in King Chulalongkorn Memorial Hospital.
BACKGROUND Gestational trophoblastic neoplasia (GTN) is a spectrum of disease with abnormal trophoblastic proliferation. Treatment is based on FIGO stage and WHO risk factor scores. Patients whose score is 12 or more are considered as at extremely high risk with a high likelihood of resistance to first line treatment. Optimal therapy is therefore controversial. OBJECTIVE This study was conduc...
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ژورنال
عنوان ژورنال: Best Practice & Research Clinical Obstetrics & Gynaecology
سال: 2021
ISSN: 1521-6934
DOI: 10.1016/j.bpobgyn.2021.01.005